Minor base sequence differences between the genomes of two strains of murine cytomegalovirus differing in virulence
- 1 March 1980
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 64 (1), 1-8
- https://doi.org/10.1007/bf01317385
Abstract
Two strains of murine cytomegalovirus (MCMV), differing in virulence towards mice, were compared for possible genetic differences. The two strains behaved identically in cell cultures, although the virulent strain gave higher yields of infectious virus in salivary glands. The viral DNAs displayed identical reassociation kinetics, but minor differences in their base sequences were revealed by restriction endonuclease profiles. The endonuclease profile of the “virulent” strain was conserved during serial high multiplicity infectionin vitro.This publication has 23 references indexed in Scilit:
- Multiple Interactions Between Murine Cytomegalovirus and Lymphoid Cells In VitroJournal of General Virology, 1978
- Resistance to Murine Cytomegalovirus Linked to the Major Histocompatibility Complex of the MouseJournal of General Virology, 1977
- Thymidine kinase activity in mouse 3T3 cells infected by murine cytomegalovirus (MCV)Virology, 1977
- Organization of ribosomal protein genes in Escherichia coli: I. Physical structure of DNA from transducing λ phages carrying genes from the aroE-str regionJournal of Molecular Biology, 1976
- Cytomegalovirus infectivity: Analysis of the phenomenon of centrifugal enhancement of infectivityVirology, 1976
- Properties of the multicapsid virions of murine cytomegalovirusVirology, 1976
- Structural and functional heterogeneity of the murine cytomegalovirus genomeVirology, 1974
- Some properties of the genome of murine cytomegalovirus (MCV)Virology, 1973
- Defective Virions of Herpes Simplex VirusesIntervirology, 1973
- THE VISCERAL LESIONS PRODUCED IN MICE BY THE SALIVARY GLAND VIRUS OF MICEThe Journal of Experimental Medicine, 1936