Formation and Stability of G‐Quadruplexes Self‐Assembled from Guanine‐Rich Strands
- 4 January 2007
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 13 (3), 945-949
- https://doi.org/10.1002/chem.200600424
Abstract
Electrospray ionization mass spectrometry (ESI-MS) was utilized to investigate the formation and stability of G-quadruplexes. For the 15 6-nt oligonucleotides tested, ESI-MS indicated that formation of a parallel tetramer quadruplex requires at least four continuous guanines in the 6-nt sequence. In addition, the G-rich strands prefer to employ “self-association” in the formation of the G-quadruplex rather than hybridized integration, and the thermodynamic-stability order of these three G-quadruplexes is Q(2)>Q(1)>Q(3).Keywords
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