EFFECT OF TRANSDERMALLY ADMINISTERED SCOPOLAMINE IN PREVENTING MOTION SICKNESS

Abstract

The efficacy of transdermally administered scopolamine was compared with the efficacy of oral dimenhydrinate and placebo therapy in the prevention of motion-induced nausea in a vertical oscillator. Medications were administered on a double-blind cross-over basis, with the order of treatments counterbalanced. Subjects (35) known to be susceptible to the stimulus were studied. A placebo effect reduced the motion sickness incidence (MSI) from 100 to 59%. Administration of dimenhydrinate reduced the MSI to 32%, and use of the transdermal therapeutic system scopolamine (TTS-scopolamine) reduced the MSI to 16%. TTS-scopolamine afforded 73% protection against motion-induced nausea, compared to 46% protection with dimenhydrinate. The TTS-scopolamine is designed to remain in the body for 72 h, providing advantages over i.m. or oral administration of scopolamine, which include reduced daily dosage and an effective alternate to the gastrointestinal tract for administrating medication at times of gastrointestinal distress.