A TEST FOR ANTI-ANDROGENS
- 1 February 1960
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. XXXIII (II), 308-316
- https://doi.org/10.1530/acta.0.xxxiii0308
Abstract
A test for anti-androgenic activity of steroid and non-steroid compounds is suggested. The method consists in the stimulation of the chick''s comb by orally administered testosterone and administering the test material either by direct inunction or by subcutaneous injection. The progestationally active steroids progesterone, 17-ethynyl-19-nortestosterone and 17 -ethynyltestosterone exhibited the most consistent anti-androgenic activity. Certain corticoids, estradiol-17 beta, benzpyrene, and methylcholanthrene were active as anti-androgens under the conditions of the test.Keywords
This publication has 4 references indexed in Scilit:
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- ANTI-ANDROGENIC ACTIVITY OF A SYNETHETIC PHENANTHRENEEndocrinology, 1958
- ANTI-GONADAL HORMONE ACTIVITY OF 11-ALPHA-HYDROXYPROGESTERONE1953
- Inhibition of Androgen-Induced Comb Growth in the Chick with MethylcholanthreneJNCI Journal of the National Cancer Institute, 1947