Diabetic Nephropathy

Abstract

SINCE the publication of the report by Kimmel-stiel and Wilson¹ in 1936, much has been written and said about the intercapillary glomerulosclerosis seen frequently at post-mortem examination in older diabetic patients. Porter and Walker,² Henderson, Sprague and Wagner,³ Rifkin and his co-workers⁴ and others^{5 6 7} have presented excellent discussions of the clinical picture considered to be due to such lesions. However, we have been impressed by the fact that in diabetic patients, both young and old, intercapillary glomerulosclerosis rarely if ever occurs as an isolated lesion and often seems relatively unimportant or may even be lacking. The renal involvement is almost . . .