THE ACIDOSIS OF GUANIDINE INTOXICATION 1

Abstract

Exps. on dogs show that guanidine intoxication causes an acidosis due primarily to increased production and defective metabolism of lactic acid. The administration of alkalinizing Na salts in the treatment of this acidosis is attended by unusual difficulties because of the danger associated with any temporary decrease in the effectiveness of Ca ions in the presence of increased guanidine. Na lactate fails to increase the alkali reserve because of the inability of the subject to utilize lactates. NaHCO3, while at times both dangerous and ineffective if used alone, can be made safe and promptly efficient if Ca medication is combined with its administration. The latter procedure also improves the condition of the subject by hastening the excretion of guanidine through improved kidney function.