Erythropoietic Stimulating Factor (ESF) as a Stimulant of Cell Growth in vitro

Abstract

Summary Cultures of 2 cell lines have been tested for their response to administration of erythropoietin (ESF). The ability of ESF to stimulate growth of cultures of human synovial membrane cells and human monocytic leukemia cells was demonstrated. ESF is ineffective in stimulating cell culture multiplication in very rapidly growing cultures. Suggestion was made that ESF be called “Nonspecific Growth Factor” (NGF).