THE INFLUENCE OF INSULIN ON THE PROTEIN METABOLISM OF NEPHRECTOMIZED DOGS

Abstract

The adm. of insulin produces a decrease in the rate of protein catabolism of the nephrectomized dog; a decrease in the rate of amino-acid excretion from the muscles of the eviscerated dog; and an increase in the utilization of exogenous amino acids by the muscles of the eviscerated dog. Insulin exerts its N-sparing action by decreasing the rate of oxidative deamini-zation in the liver, and increasing the rate of amino-acid utilization by the muscles for protein synthesis.