OBSTETRIC OUTCOME AND PROBLEMS OF MID‐TRIMESTER FETAL BLOOD SAMPLING FOR ANTENATAL DIAGNOSIS

Abstract

Detailed follow-up is presented of 335 pregnancies in which mid-trimester fetal blood sampling was performed for the diagnosis of a haemoglobinopathy, mostly β-thalassaemia. There were three twin pregnancies. Thirty-eight fetuses were lost including four in whom a diagnosis of thalassaemia major was made. Placenta-centesis was particularly associated with fetal vessel trauma, exsanguination and early intrauterine fetal death, while late complications associated with fetoscopy or failed fetoscopy necessitating subsequent placentacentesis included spontaneous abortion, leakage of amniotic fluid and premature onset of labour.