In Vitro Granulocytic Colony-Forming Potential of Bone Marrow from Patients with Granulocytopenia and Aplastic Anemia

Abstract

The colony-forming potential in agar-gel of bone marrows from patients with aplastic anemia and granulocytopenia has been studied. It has been shown that bone marrow cells from these patients retain the ability to produce colonies in vitro, but that the number of colonies formed is reduced compared to normal human bone marrow. No inhibitory effect of serum or plasma from patients with aplastic or granulocytopenic states was found upon the colony growth of normal human bone marrow.