Ureteropelvic Obstruction Caused by Candida Pyelitis in Homotransplanted Kidney

Abstract

MUCH ATTENTION has recently been directed toward the occurrence of significant and often fatal infections following organ homotransplantation and immunosuppression.^1-3 Although pulmonary involvement seems to be the most common manifestation, it is apparent that genitourinary infection is also important, particularly after renal transplantation. We have recently been caring for a patient with a renal homotransplant who acquired a Candida albicans infection in the grafted kidney and on two occasions developed ureteral obstruction. In both instances, irrigation of the collecting system with an amphotericin B solution resulted in relief of the obstruction and elimination of the fungus from the urine. Report of a Case A 48-year-old man (UH 163254), developed progressive renal insufficiency due to chronic glomerulonephritis and was referred to Thomas E. Starzl, MD, at the University of Colorado Medical Center for consideration of renal homotransplantation. On Dec 7, 1963, renal homotransplantation was carried out, the patient's sister serving