Tumor regression of human retinoblastoma in the nude mouse following photoradiation therapy: A preliminary report

Abstract

Retinoblastoma is the most common malignant intraocular neoplasm of childhood. Enucleation of both eyes is necessary in some advanced cases where radiotherapy and other modalities of treatment have failed. We present in this paper our initial observation that photoradiation therapy (the combination of the photosensitizing drug, hematoporphyrin derivative, and red light) produces marked tumor cytotoxicity in human retinoblastoma heterotransplanted into the anterior chamber of the nude mouse eye.