Magnetic induction hyperthermia for brain tumor using ferromagnetic implant with low Curie temperature

Abstract

Experimental study was made on magnetic induction hyperthermia for brain tumor using ferromagnetic implant with low Curie temperature. Thermoseed (implant) was made of nickel-palladium alloy, which was confirmed to produce enough heat by eddy current and also to have low Curie point between 43 °C–58 °C. Using this implant heating system, the effect of hyperthermia on normal rat brain and intracutaneously innoculated rat gliosarcoma (T9) were studied. Heat conduction from seed was twice as much in tumor tissue as in normal brain. It was also found that the intradermal brain tumors were completely diminished within 4 weeks by single local hyperthermia at 45 °C for 60 min.