Carcinogenic Activity of Polycyclic Pseudoazulenes Containing Both Nitrogen and Sulfur Heterocycles2

Abstract

Nine polycyclic pseudoazulenes derived from the nitrogen-and sulfur-containing heterocycles [1]benzothiopyrano[4,3-b]indole and thieno[3′,4′:5,6]thiopyrano[4,3-b]indole were tested for carcinogenicity in mice by subcutaneous injection. Three compounds, all belonging to the first group, were found to be sarcomagenic. The high activity of 6,13-dihydrobenzo[e][1]benzothiopyrano[4,3-b]indole is of particular interest because it surpasses that of the structurally related 7H-dibenzo[a,g]-carbazole.