Start of mu-chain production by the further two-step rearrangements of immunoglobulin heavy chain genes on one chromosome from a DJH/DJH configuration in an Abelson virus-transformed cell line: evidence of secondary DJH complex formation.
- 1 April 1987
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 138 (7), 2305-2310
- https://doi.org/10.4049/jimmunol.138.7.2305
Abstract
A variant was selected from an Abelson virus-transformed cell line with identifiable and distinguishable DJH rearrangements on both chromosomes. Southern blotting experiments suggested that this variant resulted from a secondary DJH complex formation accompanied with the deletion of one of the DJH rearrangements on the same chromosome. Furthermore, this variant started making mu-chains by the further functional join of a VH gene to the secondarily formed DJH complex. Thus, we describe here the first evidence of a secondary DJH complex formation.This publication has 5 references indexed in Scilit:
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