Intrauterine Growth Retardation: Pathophysiology and Possibilities for Intrauterine Treatment

Abstract

Advances in obstetrical care have decreased perinatal morbidity and mortality considerably over the past decade. Intrauterine growth retardation (IUGR) comprises an important component of the remaining morbidity and mortality. Through increased understanding of the pathophysiology of the different types of IUGR, we can begin to devise specific therapies for IUGR rather than the empiric ones currently employed. For example, it may become possible to selectively treat certain types of IUGR such as with hyperbaric oxygen therapy or specific nutritional supplementation. We review here our understanding of IUGR pathophysiology as it relates to potential therapies.