Absorption of Fluoride from Fluoride Dentifrices

Abstract

The bioavailability of fluoride (F) from NaF and Na₂PO₃F dentifrices was studied in detail in young volunteers. The method used was based on a comparison of plasma and urinary data obtained following intravenous administration of a single 3-mg dose F and ingestion of 6 g (6 mg F) of two different F dentifrices on three separate occasions. The plasma data indicated a higher degree of F bioavailability from the NaF dentifrice (111 ± 13%, SD, n = 4) as compared with theNa₂P0₃F dentifrice (96 ± 16%, SD, n = 4). Since the absorption of F from the F dentifrices was essentially total it is concluded that F dentifrices may play an important part in the daily exposure of children to F.