Amino Acid Accumulation by Kidney Cortex Slices and Intestinal Segments of Rats Bearing a Transplantable Pituitary Tumor

Abstract

In vitro studies of amino acid accumulation and incorporation into protein have been carried out in tissues from rats bearing a transplantable pituitary tumor (MtT) which produces growth hormone, prolactin and ACTH. The marked visceromegaly observed in these animals is associated with enhancement of amino acid accumulation by kidney cortex slices and jejunal segments, as well as stimulation of incorporation into protein. The effects on accumulation and incorporation are abolished by adrenalectomy, suggesting that elevated levels of circulating adrenal hormones in tumor-bearing rats are responsible for the changes observed. (Endocrinology76: 267, 1965)