Some Effects of Albumin Infusions on Renal Function and Electrolyte Excretion in Normal Man

Abstract

In 6 controlled expts. 75 g. of human salt-poor albumin were injd. rapidly into 3 normal subjects during a large water and mannitol diuresis. This resulted in an immediate 20% increase in plasma volume, a relative reduction of urine flow, no significant change in mannitol clearance, a decrease in Na and chloride excretion and an increase in K excretion. The changes in Na and chloride excretion may be related to alterations in tubular activity as indicated by changes in the fraction "excreted/ filtered," the numerical values of which are derived under the assumption that mannitol clearance and glomerular filtration rate are equivalent.