Formation of the cyclic 1,N2-glyoxal-deoxyguanosine adduct upon reaction of N-nitroso-2-hydroxymorpholine with deoxyguanosine
- 1 January 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 6 (11), 1671-1673
- https://doi.org/10.1093/carcin/6.11.1671
Abstract
N-nitroso-2-hydroxymorpholine, a mutagenic metabolite of N-nitrosomorpholine and N-nitrosodiethanolamine, reacted with deoxyguanosine at pH 7, 37°C, to give 3-(2-deoxy-β-D-erythropentofuranosyI)-6, 7-dihydro-6, 7-dihydroxyimidazo-[1, 2-a]purine-9(3H)one, which is also formed by reaction of deoxyguanosine with glyoxal. The results suggest that this adduct might be involved in DNA binding by N-nitrosomorpholine and N-nitrosodiethanolamine.This publication has 7 references indexed in Scilit:
- Identification of a nitrosamino aldehyde and a nitrosamino acid resulting from β-oxidation of N-nitrosodiethanolamineChemico-Biological Interactions, 1984
- Alcoholdehydrogenase as an activating enzyme for N-nitrosodiethanolamine (NDELA): In vitro activation of NDELA to a potent mutagen in Salmonella typhimuriumZeitschrift für Krebsforschung und Klinische Onkologie, 1984
- A STUDY OF CHEMICAL CARCINOGENESIS .66. A SENSITIVE METHOD FOR DETECTING INVIVO FORMATION OF N-NITROSOMORPHOLINE AND ITS APPLICATION TO RATS GIVEN LOW-DOSES OF MORPHOLINE AND SODIUM-NITRITE1984
- MODIFICATION OF GUANINE DERIVATIVES BY REDUCED 2-NITROIMIDAZOLES1983
- A STUDY OF CHEMICAL CARCINOGENESIS .35. METABOLIC ALPHA-HYDROXYLATION OF N-NITROSOMORPHOLINE AND 3,3,5,5-TETRADEUTERO-N-NITROSOMORPHOLINE IN THE F344 RAT1981
- Metabolism of N-nitrosomorpholine by the rat in vivo and by rat liver microsomes and its oxidation by the Fenton systemChemico-Biological Interactions, 1978
- The Reaction of Guanine Derivatives with 1,2-Dicarbonyl Compounds*Biochemistry, 1966