Inhibition of Normal Growth by Chronic Administration of Δ 9 -Tetrahydrocannabinol
- 22 October 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4007), 424-426
- https://doi.org/10.1126/science.174.4007.424
Abstract
Body weight, food and water intake, and feces weight of 20 albino rats were recorded daily for 70 days. On days 11 to 40, 12 rats received behaviorally effective doses of Δ-9-tetrahydrocannabinol, either orally or intraperitoneally. These rats ate significantly less than placebo-dosed controls during the treatment period, and gained significantly less weight. Food intake recovered in the 30-day posttreatment period, but the former drug group still weighed less than the controls on day 70. In addition, all rats who had received intraperitoneal injections of Δ-9-tetrahydrocannabinol showed evidence of chronic diffuse nonsuppurative peritonitis.Keywords
This publication has 10 references indexed in Scilit:
- l - Δ 9 - trans -Tetrahydrocannabinol in Pigeons: Tolerance to the Behavioral EffectsScience, 1970
- Auditory and Visual Threshold Effects of Marihuana in ManPerceptual and Motor Skills, 1969
- A neuropharmacological investigation of some trans-tetrahydrocannabinol derivativesPhysiology & Behavior, 1969
- 1-Δ 9 -Tetrahydrocannabinol: Neurochemical and Behavioral Effects in the MouseScience, 1969
- Effects of Cannabis sativa and lysergic acid diethylamide on a visual discrimination task in pigeonsPsychopharmacology, 1969
- Clinical and Psychological Effects of Marihuana in ManScience, 1968
- Behavioral Effects in Monkeys of Racemates of Two Biologically Active Marijuana ConstituentsScience, 1968
- Tolerance to Chronic Administration of Cannabis sativa (Marihuana) in RatsPharmacology, 1968
- Effects of some tetrahydrocannabinols on hexobarbital sleeping time and amp amphetamine induced hyperactivity in miceLife Sciences, 1967
- Isolation, Structure, and Partial Synthesis of an Active Constituent of HashishJournal of the American Chemical Society, 1964