Massive strychnine intoxication: Serial blood levels in a fatal case
- 1 January 1992
- journal article
- research article
- Published by Informa UK Limited in Journal of Toxicology: Clinical Toxicology
- Vol. 30 (2), 269-283
- https://doi.org/10.3109/15563659209038638
Abstract
A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.Keywords
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