Clinical and Analytical Validation of an Enzymometric Assay for Creatine Kinase-Mb isoenzyme

Abstract

The analytical validation of an immunoenzymometric technique for the specific measurement of the creatine kinase-MB isoenzyme is described. Its application is shown in the diagnosis of myocardial infarction. A difference in the correlation of the mass and catalytic activity of the CK-MB isoenzyme is shown between patients suffering myocardial infarction and those with skeletal muscle damage.