Development of an integrated family assessment inventory based on the Double ABCX and Circumplex models of family functioning and its clinical utility was evaluated with 121 primary family caregivers from a cognitive disorders program. The proposed model predicted a significant proportion of the variance associated with caregiver stress and strain. Several aspects of the caregiving arrangement also emerged as key features in predicting caregiver depression. These findings supported the model's central premise that both dyadic (caregiver-patient) and systemic (caregiver-family) variables are salient in assessing the impact of family caregiving with dementia.