Tolerance to Opioid Narcotics, II. Cellular Tolerance to Levorphanol in Mouse Brain
- 1 July 1970
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 66 (3), 944-951
- https://doi.org/10.1073/pnas.66.3.944
Abstract
Mice were made tolerant to a large dose of levorphanol, a congener of morphine. Then (3)H-levorphanol was given. The concentration of free, unchanged levorphanol in the brain water (ultrafiltrate) was found to be much higher than required to produce pharmacologic effects in nontolerant animals. The result indicates that tolerance arises from a diminished sensitivity to the drug at cellular or subcellular sites of drug action in the brain.Keywords
This publication has 7 references indexed in Scilit:
- Tolerance to opioid narcotics. I. Tolerance to the "running fit" caused by levorphanol in the mouse.1969
- Induction of morphine tolerance by material extracted from brain of tolerant animalsInternational Journal of Neuropharmacology, 1966
- DISTRIBUTION OF N-C14-METHYL LABELED MORPHINE .1. CENTRAL NERVOUS SYSTEM OF NONTOLERANT AND TOLERANT DOGS1962
- CONCENTRATION OF MORPHINE IN BLOOD AND BRAIN AFTER INTRAVENOUS INJECTION OF MORPHINE IN NON-TOLERANT, TOLERANT AND NEOSTIGMINE-TREATED RATS1956
- THE DISTRIBUTION AND FATE OF MORPHINE IN THE NON-TOLERANT AND TOLERANT MONKEY1956
- PLASMA LEVELS, URINARY AND FECAL EXCRETION OF MORPHINE IN NON-TOLERANT AND TOLERANT DOGS1954
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951