Effect of the Amount of Tissue Grafted Upon Survival of Skin Homografts.

Abstract

Summary 1. Female mice of the C57B1 (Subline 1) strain capable of rejection of small male skin isografts regularly accepted large male skin isografts. 2. Large homologous skin grafts between genetically closely related strains were regularly rejected as were small skin homografts. 3. Large skin homografts between strains of mice characterized by strong histocompatibility differences regularly resulted in early death of the recipient. 4. Tolerance of C57B1(Subline 1) female mice to male skin isografts induced by spleen cell injection could be transferred by injection of spleen cells from tolerant donors to new females during the post-neonatal period. Attempts to transfer tolerance induced with a large skin graft were unsuccessful.