THE EFFECT OF ASPIRIN ON 5‐HYDROXYTRYPTAMINE UPTAKE AND RELEASE BY HUMAN PLATELETS
Open Access
- 1 May 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 57 (1), 149-151
- https://doi.org/10.1111/j.1476-5381.1976.tb07665.x
Abstract
The influence of aspirin on 5-hydroxytryptamine (5-HT) uptake and storage by human blood platelets has been investigated. Uptake of 5-HT was strongly inhibited. In 30 min aspirin released 50% of the 5-HT that had been incorporated into the platelets prior to the addition of the aspirin. These results are discussed in terms of possible interference with a 5-HT membrane receptor and the impairment of 5-HT storage in the dense granules.Keywords
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