SECRETION OF NICOTINIC ACID BY BIOTIN-DEPENDENT YEASTS

Abstract
The effect of biotin on nicotinic acid secretion by each of 8 yeasts was investigated; in all but 2 of these positive evidence was obtained for a link between the requirement for biotin and retention of nicotinic acid. Examination of the effect of aspartic acid on nicotinic acid secretion by Saccharomyces cerevisiae indicated that the aspartate-stimulation of growth observed at suboptimal concentrations of biotin is not associated with nicotinic acid secretion.