Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1genes
Open Access
- 16 October 2008
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 8 (1), 299
- https://doi.org/10.1186/1471-2407-8-299
Abstract
Chronic myelomonocytic leukemia (CMML) is a hematological disease close to, but separate from both myeloproliferative disorders (MPD) and myelodysplastic syndromes and may show either myeloproliferative (MP-CMML) or myelodysplastic (MD-CMML) features. Not much is known about the molecular biology of this disease.Keywords
This publication has 48 references indexed in Scilit:
- High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemiaLeukemia, 2008
- Integrated Profiling of Basal and Luminal Breast CancersCancer Research, 2007
- Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1–like phenotypeNature Genetics, 2007
- Gene expression profiling separates chronic myelomonocytic leukemia in two molecular subtypesLeukemia, 2007
- Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPα interactionThe EMBO Journal, 2007
- The impact of translocations and gene fusions on cancer causationNature Reviews Cancer, 2007
- Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11Oncogene, 2007
- Mutations of thePTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocationsGenes, Chromosomes and Cancer, 2007
- Germline gain-of-function mutations in SOS1 cause Noonan syndromeNature Genetics, 2006
- AML1/Runx1 Recruits Calcineurin to Regulate Granulocyte Macrophage Colony-stimulating Factor by Ets1 ActivationPublished by Elsevier ,2004