Fresh and Cultured Thyroid Gland
- 1 February 1976
- journal article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 183 (2), 146-156
- https://doi.org/10.1097/00000658-197602000-00011
Abstract
Isogeneic or allogeneic thyroid glands were implanted into thyroidectomized recipeint rats. These grafts, either fresh or cultured, were placed in hamstring muscle pocket or under the renal capsule. Survival and function of the grafts were evaluated by: restoration of normal levels of serum thyroxine, weight gain, kidney transamidinase (a thyroxine-induced enzyme), and histological appearance of re-excised implants. A isografts, fresh and cultured, functioned well as ectopic thyroid glands, though restoration of normal serum thyroxine levels was more rapid for the fresh implants. Fresh allografts functioned transiently but then failed due to rejection. No function was detected for cultured allografts, and rejection was seen histologically. The rat thyroid allograft therefore differs from the rat parathyroid allograft, which often can function for several months despite histological evidence of rejection. Maintenance in tissue culture prior to implantation does not appear to alter the longterm immunogenicity of either organ.Keywords
This publication has 33 references indexed in Scilit:
- ALTERED ALLOTRANSPLANTABILITY OF BALB/c LEYDIG CELL TUMOR AFTER ORGAN CULTURE OR CELL SUSPENSIONTransplantation, 1975
- OVARIAN ALLOGRAFT SURVIVAL PROLONGATION AFTER PASSAGE IN VITROTransplantation, 1974
- Transplantation of fresh and cultured parathyroid glands in the ratThe American Journal of Surgery, 1974
- Conference on Beta Cell Function, Transplantation, and Implantable Glucose Sensors: A summaryMetabolism, 1974
- ALLOGENEIC TRANSPLANTATION OF ORGAN CULTURES WITHOUT IMMUNOSUPPRESSION AN EVALUATION USING ADULT MOUSE SKINTransplantation, 1974
- SKELETAL MUSCLE AS A PRIVILEGED SITE FOR ORTHOTOPIC SKIN ALLOGRAFTSThe Journal of Experimental Medicine, 1973
- Importance of implantation site of pancreatic islet isografts in treatment of experimental diabetes.1973
- Transplantation of intact pancreatic islets in rats.1972
- Growth of Tumors in Allogeneic Hosts After Organ Culture Explantation. II. Tumor-Host Interactions2JNCI Journal of the National Cancer Institute, 1969
- A QUANTATIVE COMPARISON STUDY OF IMMUNIZING ABILITY OF DIFFERENT TISSUESAnnals of the New York Academy of Sciences, 1964