Cyclisation of farnesyl pyrophosphate to γ-bisabolene in tissue cultures of Andrographis paniculata

Abstract

Tissue Cultures of Andrographis paniculate transform trans,trans-[1-³H₂; 12,13-¹⁴C₂]farnesy pyrophosphate, and (3R,5R)- and (3R,5S)-(5-³H)-mevalonolactones into Z-γ-bisabolene without tritium loss; the absolute configuration of paniculide B (7a) has been determined by an X-ray crystal structure determination of its bis-p-bropmobenzoate.