Attenuation of Virulence by Disruption of the Mycobacterium tuberculosis erp Gene
- 23 October 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 282 (5389), 759-762
- https://doi.org/10.1126/science.282.5389.759
Abstract
The virulence of the mycobacteria that cause tuberculosis depends on their ability to multiply in mammalian hosts. Disruption of the bacterial erp gene, which encodes the exported repetitive protein, impaired multiplication of M. tuberculosis andM. bovis Bacille Calmette-Guérin in cultured macrophages and mice. Reintroduction of erp into the mutants restored their ability to multiply. These results indicate thaterp contributes to the virulence of M. tuberculosis.Keywords
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