INVITRO BINDING-AFFINITY OF NOVEL SYNTHETIC POLYPRENOIDS (POLYPRENOIC ACIDS) TO CELLULAR RETINOID-BINDING PROTEINS

Abstract

The in vitro binding affinity of new synthetic polyprenoids [potential antitumor agents] to cellular retinoid-binding proteins was investigated. Among 10 synthetic polyprenoic acid derivatives, 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid (compound I) had the strongest binding affinity to cellular retinoic acid-binding protein (CRABP) from rat testis. Suitable carbon chain length and double bond arrangement are both essential for binding affinity to CRABP. Compound I displayed a binding affinity to cellular retinoid receptors obtained from precancerous tissues such as mouse skin papillomas and rat liver hyperplastic nodules experimentally induced.