Management of Endometrial Hyperplasia With a Levonorgestrel-releasing Intrauterine System: Single Arm, Prospective Multicenter Study: Korean Gynecologic Oncology Group Study (KGOG2006)
Open Access
- 7 April 2011
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Japanese Journal of Clinical Oncology
- Vol. 41 (6), 817-819
- https://doi.org/10.1093/jjco/hyr048
Abstract
A prospective multicenter trial has been commenced in Korea to investigate the treatment efficacy of the levonorgestrel-releasing intrauterine system in patients with endometrial hyperplasia. The levonorgestrel-releasing intrauterine system is an alternative to oral progesterone without the disadvantages of oral progestogens. Therefore, we hypothesize that if the therapeutic efficacy of the levonorgestrel-releasing intrauterine system is similar to or greater than that of oral progesterone, the levonorgestrel-releasing intrauterine system could become the standard treatment for endometrial hyperplasia patients who do not want a hysterectomy. The levonorgestrel-releasing intrauterine system is inserted into uteri of patients with histologically confirmed endometrial hyperplasia. An office endometrial aspiration biopsy and transvaginal ultrasound are conducted every 3 months at an outpatients clinic. The primary endpoint is the response rate. The secondary endpoint is to estimate the consistency of the results of the office endometrial aspiration biopsy during the levonorgestrel-releasing intrauterine system being placed in uterus and a dilatation and curettage procedure.Keywords
This publication has 7 references indexed in Scilit:
- The effectiveness of levonorgestrel releasing intrauterine system in the treatment of endometrial hyperplasia in Korean womenJournal of Gynecologic Oncology, 2010
- The effectiveness of a levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of endometrial hyperplasia—A long-term follow-up studyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2008
- Histologic Alterations in Endometrial Hyperplasia and Well-differentiated Carcinoma Treated With ProgestinsThe American Journal of Surgical Pathology, 2007
- Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-α and ER-β) in human endometrial hyperplasiaGynecologic Oncology, 2006
- Treatment of nonatypical and atypical endometrial hyperplasia with a levonorgestrel-releasing intrauterine systemAmerican Journal of Obstetrics and Gynecology, 2003
- Progestin Treatment of Atypical Hyperplasia and Well-Differentiated Carcinoma of the Endometrium in Women Under Age 40Obstetrics & Gynecology, 1997
- The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patientsCancer, 1985