Studies on β-Lactam Antibiotics for Medicinal Purpose. VIII. Synthesis of 7-[D(-)-α-(4-Alkyl-2, 3-dioxo-1-piperazinecarboxamido) phenylacetamido]-cephalosporanic Acids and Structure-Antibacterial Activity

Abstract

7-[D(-)-.alpha.-(4-Alkyl-2,3-dioxo-1-piperazinecarboxamido)phenylacetamido]-3-substituted methyl-3-cephem-4-carboxylic acids were prepared. In vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris and Klebsiella pneumoniae was tested and it had a strong antibacterial activity against gram-negative bacilli, especially to Pseudomonas aeruginosa and Proteus vulgaris.