Pneumoencephalographic evidence of brain atrophy in acute and chronic schizophrenic patients
- 1 November 1982
- journal article
- research article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 66 (5), 374-383
- https://doi.org/10.1111/j.1600-0447.1982.tb06719.x
Abstract
Pneumoencephalography (PEG) was carried out in 50 patients of both sexes consecutively discharged from a psychiatric department with a diagnosis of acute schizophrenia. At clinical follow-up with a mean observation time of 8 years the diagnosis was verified in 38 patients, while 12 were considered to have had a reactive psychosis. The PEG findings and clinical findings in these two groups are compared, and compared to corresponding findings in 101 chronic schizophrenics previously studied with the same method. Linear measurements were used in estimating the size of the ventricular system, which was safely within normal limits in all but three of the 50 patients. Mean ventricular size did not differ significantly in the two groups of acute psychoses. No case of cortical atrophy was found. More than half of the chronic schizophrenics had abnormal PEG's, the typical finding being a bilateral enlargement of the ventricular system. The mean size of all parts of the ventricular system was significantly higher than in the acute schizophrenics. A close correlation was found between mental deterioration and ventricular enlargement. The most reasonable explanation of these findings is that schizophrenia is an inborn error of metabolism, disturbing normal brain function and in the long run leading to degenerative changes of the nervous tissue.Keywords
This publication has 26 references indexed in Scilit:
- Cortical and central atrophy in chronic schizophreniaActa Psychiatrica Scandinavica, 1982
- Computerized tomography of the brain in schizophrenic patients.Acta Psychiatrica Scandinavica, 1981
- Size of Cerebral Ventricles in 66 Psychiatric PatientsThe British Journal of Psychiatry, 1978
- Age Disorientation in Chronic Schizophrenia: The Nature of the Cognitive DeficitThe British Journal of Psychiatry, 1978
- CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIAThe Lancet, 1976
- The Brain Stem in PsychosisThe British Journal of Psychiatry, 1975
- Schizophrenic symptomatology as a function of probability of cerebral damage.Journal of Abnormal Psychology, 1973
- Lumbar Air Encephalography in Chronic Schizophrenia: A Controlled ExperimentThe British Journal of Psychiatry, 1966
- Observations on Encephalographic Findings in Cerebral TraumaJournal of Neurosurgery, 1946
- Encephalographische Studien an chronisch SchizophrenenArchiv Fur Psychiatrie Und Nervenkrankheiten, 1927