Physiologic Hyperbilirubinemia in the Neonatal Period

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Abstract
THE degree and duration of hyperbilirubinemia during neonatal life result from many influences unique to the newborn period that serve either to increase the rate of formation of bilirubin or to retard its excretion. The present paper reviews recent concepts that elucidate several causes of hyperbilirubinemia that are unrelated to hemolytic disease.The overall hepatic excretion of bilirubin involves at least three separate processes1: Uptake. Bilirubin is transported in the serum attached to serum albumin and enters the sinusoidal circulation of the liver from either the hepatic artery or the portal vein, where it is taken up by . . .