The Ultrastructure of Dyserythropoiesis in Aplastic Anaemia

Abstract

EM of erythropoiesis in aplastic anemia [human] demonstrated some unique features of dyserythropoiesis at the ultrastructural level, which contribute to understanding the morphological features seen in the light microscope. The presence of qualitative defects in erythropoiesis in aplastic conditions was confirmed. The alterations included bi- and multinucleated cells, intercellular bridges containing microtubules, internuclear chromatin bridges, irregular nuclear shapes, juxta-nuclear and peripheral cisternal structures, ringed sideroblasts, a diversity of intranuclear inclusions, nuclear clefts in both eu- and heterochromatin and a variety of anomalies of the nuclear membrane. The significance of the occurrence of these anomalies in aplastic anemia is considered and the role of the nuclear membrane and of endoplasmic reticulum in the pathogenesis of aplastic anemia is discussed.