Jaundice Phototherapy: Micro Flow-Cell Photometry Reveals Rapid Biliary Response of Gunn Rats to Light
- 1 September 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 201 (4358), 829-831
- https://doi.org/10.1126/science.581101
Abstract
Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.Keywords
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