DIFFERENTIAL EFFECTS OF SOME PHENOTHIAZINE DERIVATIVES AGAINST CALCIUM-INDUCED VENTRICULAR ARRHYTHMIAS IN THE ISOLATED RABBIT HEART
- 1 November 1964
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 42 (6), 845-853
- https://doi.org/10.1139/y64-094
Abstract
This paper deals with the effects of five phenothiazine derivatives and quinidine against ventricular fibrillation induced in the isolated rabbit heart by small amounts of calcium chloride. Chlorpromazine and promethazine were more potent than quinidine in raising the calcium threshold for fibrillation. On the other hand, prochlorperazine and diethazine exerted biphasic effects: small concentrations increased the sensitivity of the heart to calcium chloride or induced fibrillation without calcium; higher concentrations had antifibrillatory effects and markedly depressed atrioventricular conduction. Thioproperazine was profibrillatory at all concentrations tested.Keywords
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