THE LH RESPONSE TO LH-RELEASING HORMONE IN CHILDREN WITH TRUE ISOSEXUAL PRECOCIOUS PUBERTY TREATED WITH CYPROTERONE ACETATE
- 1 May 1975
- journal article
- Published by Wiley in Clinical Endocrinology
- Vol. 4 (3), 305-311
- https://doi.org/10.1111/j.1365-2265.1975.tb01538.x
Abstract
Fourteen girls and one boy with isosexual precocious puberty were submitted to LHRH stimulation tests, during and without therapy with cyproterone acetate. In addition, fourteen girls with isosexual precocious puberty not receiving any therapy were tested and served as controls. It was found that cyproterone acetate induces suppression of the responsiveness of the pituitary gland to secrete LH on LHRH stimulation. Daily oral therapy was found to be more effective than the regimen of intramuscular depot injections. These findings demonstrate that cyproterone acetate has an antigonadotrophic effect.Keywords
This publication has 14 references indexed in Scilit:
- Cyproterone acetate in treatment of precocious puberty.Archives of Disease in Childhood, 1976
- THE LH RESPONSE TO LH-RELEASING HORMONE IN CHILDREN WITH TRUE ISOSEXUAL PRECOCIOUS PUBERTY TREATED WITH CYPROTERONE ACETATEClinical Endocrinology, 1975
- Behandlung mit AntiandrogenenDeutsche Medizinische Wochenschrift (1946), 1974
- Endocrinology of puberty: II. Aberrations of sexual maturationThe Journal of Pediatrics, 1973
- IMPROVEMENT OF ADULT HEIGHT PROGNOSIS IN PRECOCIOUS PUBERTY BY CYPROTERONE ACETATEActa Paediatrica, 1973
- SERUM LUTEINIZING HORMONE AND FOLLICLE STIMULATING HORMONE IN NORMAL CHILDREN AND PATIENTS WITH VARIOUS CLINICAL DISORDERSClinical Endocrinology, 1973
- Some physiological and clinical aspects of puberty.Archives of Disease in Childhood, 1973
- Studies with Synthetic LH-Releasing Hormone in the HumanNeuroendocrinology, 1973
- ELEVATION OF SERUM GONADOTROPINS (LH AND FSH) AFTER RELEASING HORMONE (LH-RH) INJECTION IN NORMAL CHILDREN AND IN PATIENTS WITH DISORDERS OF PUBERTY1Journal of Clinical Endocrinology & Metabolism, 1972
- BIOLOGICAL ACTIVITY OF ANTIANDROGENSBritish Journal of Dermatology, 1970