THE EFFECT OF URETHANE ON THE CONSUMPTION OF OXYGEN AND THE RATE OF CELL DIVISION IN THE CILIATE TETRAHYMENA GELEII
Open Access
- 20 May 1944
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 27 (5), 461-468
- https://doi.org/10.1085/jgp.27.5.461
Abstract
The inhibition of O2 consumption produced by a series of concs. of ethyl carbamate has been measured in the protozoan T. geleii. The relation found between the narcotic conc. and its effect on respiration leads to the conclusion that urethane has 2 distinct modes of action in this cell. The respiratory data can be accurately predicted by assuming that the inhibitor acts on 2 independent parallel respiratory systems. Complete suppression of cell division in this organism is brought about by approx. 0.1 [image] urethane. Urethane concs. up to 0.1 M affect primarily only one of the 2 postulated respiratory systems. The mechanism of the narcosis of cell division in this organism by urethane thus appears to be inhibition of this "activity" system.This publication has 4 references indexed in Scilit:
- Narcosis.1942
- THE NORMAL GROWTH AND RESPIRATION OF TETRAHYMENA GELEIIThe Biological Bulletin, 1942
- The separation of an “activity” metabolism from the total respiration of yeast by the effects of Ethyl CarbamateJournal of Cellular and Comparative Physiology, 1942
- Growth of protozoa in pure culture. I. Effect upon the growth curve of the age of the inoculum and of the amount of the inoculumJournal of Experimental Zoology, 1935