Self-Assembly of β-Cyclodextrin in Water. Part 1: Cryo-TEM and Dynamic and Static Light Scattering
- 5 January 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 22 (4), 1478-1484
- https://doi.org/10.1021/la052878f
Abstract
In this article, we report evidence of β-cyclodextrin (β-CD) self-aggregation in water. A critical aggregation concentration (cac) between 2 and 3 mM was determined by using dynamic (DLS) and static (SLS) light scattering to investigate the presence of β-cyclodextrin aggregates. Transmission electron microscopy at cryogenic temperature (Cryo-TEM) was used to detect the structural features of cyclodextrin self-aggregates. The results show the occurrence of polymorphism depending on the β-CD concentration: polydisperse nearly spherical objects with diameters of about 100 nm are present at lower concentrations, whereas micrometer planar aggregates are predominant at higher concentrations.Keywords
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