Further Psychometric Evaluation of the Effect of Mephenesin on Anxiety

Abstract

In a previous article (Ewing and Mendenhall, 1953) we reported the results of an experimental investigation devised to test the effects of mephenesin on anxiety. Rigid controls were employed, involving the use of inert tablets for comparison purposes, as well as other safeguards to eliminate subjective factors on the part of the examiners. Using the Digit Span test-retest as an index of anxiety, it was found that no statistically significant diminution of anxiety was obtained with doses of up to 2.0 gm. mephenesin orally.