Circadian rhythm of lithium toxicity in mice
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 56 (1), 113-114
- https://doi.org/10.1007/bf00571418
Abstract
The existence of cyclical (circadian) variations in lithium toxicity in mice was determined. Mice, standardized to a light-dark cycle, were injected with lithium chloride (940 mg/kg) at one of six times (20:00, 24:00, 4:00, 8:00, 12:00, and 16:00) and subsequently observed for mortality over 28 h. A significant (P<0.01) time-of-day effect was found for lithium-induced lethality, with highest lethality following injection at 12:00.This publication has 5 references indexed in Scilit:
- Lethal effects of physostigmine plus lithium in ratsPsychopharmacology, 1977
- Low Renin, “Normal” Aldosterone and Hypertension: Circadian Rhythm of Renin, Aldosterone, Cortisol and Growth HormoneJournal of Clinical Endocrinology & Metabolism, 1974
- LithiumClinical Toxicology, 1973
- Increased Tolerance of Leukemic Mice to Arabinosyl Cytosine with Schedule Adjusted to Circadian SystemScience, 1972
- Circadian ChronopharmacologyAnnual Review of Pharmacology, 1971