Expression of cellular myc and mos genes in undifferentiated B cell lymphomas of Burkitt and non-Burkitt types.
Open Access
- 1 April 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (7), 1947-1950
- https://doi.org/10.1073/pnas.80.7.1947
Abstract
Burkitt lymphomas contain reciprocal translocations between chromosome 8 and 1 of the chromosomes containing the immunoglobulin gene loci, prompting speculation that consequent activation of a crucial gene(s) on chromosome 8 might be involved in the generation of these tumors. Recently the human counterparts of the retroviral oncogenes v-myc and v-mos were mapped to chromosome 8. The level of transcription of the cellular myc and mos genes was analyzed in a variety of undifferentiated B cell lymphomas of Burkitt and non-Burkitt type that possess either an 8;14 or an 8;22 translocation. These lines expressed 2- to 5-fold more myc-specific RNA than do B cell lines without a translocation. Tumor cell lines of American origin with an 8;14 or 8;22 translocation expressed similar amounts of myc-specific RNA. Tumor cell lines of African origin contained slightly higher levels of myc-specific RNA than did those of American origin. Level of expression does not appear to correlate with the presence or absence of Epstein-Barr virus. A major increase in the transcription of this gene secondary to translocation is unlikely to be the cause of Burkitt lymphoma. There was not evidence of mos-related transcripts in any of the cell lines tested.This publication has 38 references indexed in Scilit:
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