Optimum Conditions for the Local (Intravaginal) Action of Oestrogens

Abstract

The optimum conditions for the intravaginal administration of oestrogens are obtained by the use of 1 per cent. aqueous egg albumin as solvent, and two or four injections spread over 24-86 hr. The administration of oestrone, oestradiol-8,17,B, and diethylstilboestrol in distilled water by four injections in 86 hr gives a close approximation to, the optimum. Oestriol, however, has considerably reduced activity when administered under these conditions.