The Effect of Bordetella Pertussis on the Antibody Response in Mice to Type III Pneumococcal Polysaccharide
- 1 April 1976
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 116 (4), 989-993
- https://doi.org/10.4049/jimmunol.116.4.989
Abstract
The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of SIII. In contrast, the antibody response to high doses of SIII was enhanced by B. pertussis. When SIII alone was injected, only 19S antibody was detected. However, when B. pertussis was administered with either optimal or high doses of SIII, 7S as well as 19S antibody against SIII was produced.This publication has 2 references indexed in Scilit:
- Accelerated and prolongated multiplication of antibody-forming spleen cells byBordetella pertussis in mice immunized with sheep red blood cellsCellular and Molecular Life Sciences, 1967
- Comparison of Bordetella Pertussis Cells and Freund's Adjuvant with Respect to Their Antibody Inducing and Anaphylactogenic PropertiesThe Journal of Immunology, 1963