Lupus Erythematosus Tumidus
Open Access
- 1 March 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 145 (3), 244-248
- https://doi.org/10.1001/archdermatol.2008.592
Abstract
Lupus erythematosus tumidus (LET), first reported by Gougerot and Burnier1 in 1930, is a highly photosensitive skin disorder with distinct clinical and histopathologic characteristics. Most experts nowadays agree that LET is a distinct subtype of cutaneous lupus erythematosus (CLE). Lupus erythematosus tumidus is typically found on sun-exposed areas of the body and presents as edematous, urticarialike papules and plaques with a tendency to produce annular formations. In contrast to discoid lupus erythematosus (DLE) or subacute CLE (SCLE), LET does not resolve with residual scarring and hyperpigmentation or hypopigmentation. Histopathologic characteristics of LET include perivascular and periadnexal lymphocytic infiltrates as well as interstitial mucin deposition. In contrast to DLE or SCLE, LET shows no or only slight vacuolar degeneration of the dermoepidermal junction.Keywords
This publication has 15 references indexed in Scilit:
- Smoking as a trigger for inflammatory rheumatic diseasesCurrent Opinion in Rheumatology, 2007
- Cigarette smoking and the risk of systemic lupus erythematosus and rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2006
- The CLASI (Cutaneous Lupus Erythematosus Disease Area and Severity Index): An Outcome Instrument for Cutaneous Lupus ErythematosusJournal of Investigative Dermatology, 2005
- Cigarette smoking and systemic lupus erythematosus: A smoking gun?Autoimmunity, 2005
- Cigarette smoking and the risk of systemic lupus erythematosus: A meta‐analysisArthritis & Rheumatism, 2004
- EFFECTS OF CIGARETTE SMOKE EXPOSURE AND CESSATION ON INFLAMMATORY CELLS AND MATRIX METALLOPROTEINASE ACTIVITY IN MICEExperimental Lung Research, 2004
- Relation between markers of systemic vascular inflammation and smoking in womenThe American Journal of Cardiology, 2002
- Management of skin disease in patients with lupus erythematosusBest Practice & Research Clinical Rheumatology, 2002
- Effects of smoking on activation markers, Fas expression and apoptosis of peripheral blood lymphocytesEuropean Journal of Clinical Investigation, 2001
- Fractionation of Aqueous Cigarette Tar Extracts: Fractions That Contain the Tar Radical Cause DNA DamageChemical Research in Toxicology, 1998