Clinical Significance of Pharmacokinetic Models of Hepatic Elimination
- 1 January 1990
- journal article
- review article
- Published by Springer Nature in Clinical Pharmacokinetics
- Vol. 18 (1), 61-76
- https://doi.org/10.2165/00003088-199018010-00004
Abstract
Various pharmacokinetic models, both simple and complex, have been developed to describe the way in which the rate of hepatic elimination of drugs depends on hepatic blood flow, hepatic intrinsic...Keywords
This publication has 95 references indexed in Scilit:
- Clinical applicability of current pharmacokinetic models: Splanchnic elimination of 5-fluorouracil in cancer patientsJournal of Pharmacokinetics and Biopharmaceutics, 1988
- On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic eliminationJournal of Theoretical Biology, 1987
- Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in manLiver International, 1987
- The Pharmacokinetics of Antiarrhythmic Agents in Pregnancy and LactationClinical Pharmacokinetics, 1987
- A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activityJournal of Pharmacokinetics and Biopharmaceutics, 1986
- A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerationsJournal of Pharmacokinetics and Biopharmaceutics, 1986
- Influence of Food Intake on Presystemic Clearance of DrugsClinical Pharmacokinetics, 1983
- Hepatic Disease and Drug PharmacokineticsClinical Pharmacokinetics, 1980
- Hepatic elimination of flowing substrates: The distributed modelJournal of Theoretical Biology, 1978
- Enzymatic elimination of substrates flowing through the intact liverJournal of Theoretical Biology, 1976